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  2. FDA Adverse Event Reporting System - Wikipedia

    en.wikipedia.org/wiki/FDA_Adverse_Event...

    Further, the FDA does not receive all adverse event reports that occur with a product. Many factors can influence whether or not an event will be reported, such as the time a product has been marketed and publicity about an event. Therefore, FAERS cannot be used to calculate the incidence of an adverse event in the U.S. population.

  3. Investigator's brochure - Wikipedia

    en.wikipedia.org/wiki/Investigator's_brochure

    In drug development and medical device development [1] the Investigator's Brochure (IB) is a comprehensive document summarizing the body of information about an investigational product ("IP" or "study drug") obtained during a drug trial. The IB is a document of critical importance throughout the drug development process and is updated with new ...

  4. MedWatch - Wikipedia

    en.wikipedia.org/wiki/MedWatch

    MedWatch was founded in 1993 to collect data regarding adverse events in healthcare. An adverse event is any undesirable experience associated with the use of a medical product. The MedWatch system collects reports of adverse reactions and quality problems of drugs and medical devices but also for other FDA-regulated products (such as dietary ...

  5. Office for Human Research Protections - Wikipedia

    en.wikipedia.org/wiki/Office_for_Human_Research...

    The office's primary duty is the implementation of 45 CFR 46, a set of regulations for Institutional Review Boards (IRBs) that mirrors the U.S. Food and Drug Administration (FDA) regulation that covers clinical research conducted by pharmaceutical companies as well as other regulations under the guidance of the Federal Policy for the Protection ...

  6. CFR - Code of Federal Regulations Title 21

    highline.huffingtonpost.com/miracleindustry/...

    drug product sponsored by the applicant, and all other information about the drug pertinent to an evaluation of the application that is received or otherwise obtained by the applicant from any source. FDA will maintain guidance documents on the format and content of

  7. Pharmacovigilance - Wikipedia

    en.wikipedia.org/wiki/Pharmacovigilance

    Spontaneous reporting is the core data-generating system of international pharmacovigilance, relying on healthcare professionals (and in some countries consumers) to identify and report any adverse events to their national pharmacovigilance center, health authority (such as the European Medicines Agency or FDA), or to the drug manufacturer ...

  8. Medical device reporting - Wikipedia

    en.wikipedia.org/wiki/Medical_device_reporting

    Medical device reporting (MDR) is the procedure for the Food and Drug Administration to get significant medical device adverse events information from manufacturers, importers and user facilities, so these issues can be detected and corrected quickly, and the same lot of that product may be recalled.

  9. Serious adverse event - Wikipedia

    en.wikipedia.org/wiki/Serious_adverse_event

    In drug development, serious adverse event (SAE) is defined as any untoward medical occurrence during a human drug trial that at any dose Results in death; Is life-threatening; Requires inpatient hospitalization or causes prolongation of existing hospitalization; Results in persistent or significant disability/incapacity