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An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. Chirality can be observed when the geometric ...
Enantiopure dexpramipexole has essentially no dopamine agonist activity and shares no other pharmacologic similarity to pramipexole. [10] In contrast, pramipexole the (S)-enantiomer is a dopamine agonist and is an approved drug (Mirapex) used in Parkinson's disease.
Globally drug companies and regulatory agencies have an inclination towards the development of unichiral drugs as a consequence of the increased understanding of the differing biological properties of individual enantiomers of a racemic therapeutics. Most of these unichiral drugs are the consequence of chiral switch approach. The table below ...
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Levoamphetamine as an enantiopure drug has been studied in the past in a variety of contexts. [11] These include its effects in and/or treatment of mood , [ 11 ] " minimal brain dysfunction ", [ 71 ] narcolepsy , [ 11 ] [ 72 ] " hyperkinetic syndrome " and aggression , [ 73 ] [ 15 ] sleep , [ 74 ] [ 75 ] schizophrenia , [ 76 ] wakefulness ...
Researchers from The Institute of Cancer Research in London have developed a new test that can predict colorectal cancer risk in people with IBD with more than 90% accuracy.
The drug, suzetrigine, received the FDA's official stamp of approval Thursday to be sold as a 50-milligram prescription pill taken every 12 hours, according to a press release.
Largest-ever Ozempic and GLP-1 drug study finds they lower risk of 42 health conditions, including heart attacks and Alzheimer’s disease. Carolyn Barber. Updated January 21, 2025 at 12:27 PM.