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Transitional cell carcinoma is a type of cancer that arises from the transitional epithelium, a tissue lining the inner surface of these hollow organs. [1] It typically occurs in the urothelium of the urinary system ; in that case, it is also called urothelial carcinoma .
Transitional cell carcinoma is the most common form of cancer in the lower urinary tract—the bladder and urethra. This video discusses the pathophysiology, signs and symptoms, diagnosis, and treatment of transitional cell carcinoma.
Transitional cell carcinoma is the leading type of bladder cancer, occurring in 9 out of 10 cases. [11] It is also the leading cause of cancer of the ureter, urethra, and urachus, and the second leading cause of cancer of the kidney. Transitional cell carcinoma can develop in two different ways.
Bladder tumors are classified by their appearance under the microscope, and by their cell type of origin. Over 90% of bladder tumors arise from the cells that form the bladder's inner lining, called urothelial cells or transitional cells; the tumor is then classified as urothelial cancer or transitional cell cancer.
The most common histology seen in primary urethral cancer (a cancer which originates in the urethra, as opposed to cancer cells from elsewhere in the body which metastasize to the area) is urothelium, a type of transitional epithelium. Urothelial cell cancers comprise just over half of primary urethral cancers.
Ureteral cancer is usually a transitional cell carcinoma. [ 2 ] [ 4 ] Transitional cell carcinoma is "a common cause of ureter cancer and other urinary (renal pelvic) tract cancers." [ 1 ] Because the inside of the ureters and the inside of the bladder contain the same cell type, people who have been diagnosed with ureteral cancer are more ...
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