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Ziconotide, sold under the brand name Prialt, also called intrathecal ziconotide (ITZ) because of its administration route, is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide. [2] It is 1,000 times as powerful as morphine.
The venom of cone snails contains hundreds of different compounds, and its exact composition varies widely from one species to another. The toxins in cone snail venom are referred to as conotoxins, and are composed of various peptides, each targeting a specific nerve channel or receptor. Some cone snail venoms also contain a pain-reducing toxin.
Conus magus, common name the magical cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies. [2] Like all species within the genus Conus, these snails are predatory and venomous. Their venom contains conotoxins which have powerful neurotoxic effects.
Gastridium geographus (Linnaeus, 1758 ) Conus geographus, popularly called the geography cone or the geographer cone, is a species of predatory cone snail. It lives in reefs of the tropical Indo-Pacific, and hunts small fish. While all cone snails hunt and kill prey using venom, the venom of Conus geographus is potent enough to kill humans.
Cone snail venom apparatus. There are approximately 30 records of humans killed by cone snails. Human victims suffer little pain, because the venom contains an analgesic component. Some species reportedly can kill a human in under five minutes, thus the name "cigarette snail" as supposedly one only has time to smoke a cigarette before dying.
Conus victoriae, common name the Queen Victoria cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies. [1] Like all species within the genus Conus, these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully or not ...
Biochemist. Awards. National Scientist of the Philippines. Lourdes J. Cruz (born May 19, 1942) is a Filipino biochemist whose research has contributed to the understanding of the biochemistry of toxic peptides from the venom of fish-hunting Conus marine snails. [1] Throughout the Philippines, she is known as the Sea Snail Venom Specialist.[2]
Fossil Conus pelagicus from the Pliocene of Cyprus. Conus is a genus of venomous and predatory sea snails, or cone snails, marine gastropod mollusks in the family Conidae. [ 1] Prior to 2009, it included all cone snail species but is now more precisely defined, as are other cone snail genera.