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Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. [1] [5] [11] However, other mechanisms might also be involved in its effects. [1] [5] [11] Chemically, armodafinil is the enantiopure (R)-(–)-enantiomer of the racemic mixture modafinil (brand name Provigil).
One company had attempted to get a New Dietary Ingredient pre-market notification approved for adrafinil in 2017, but the Food and Drug Administration rejected [22] it: “For the reasons discussed above, the information in [this pre-market] notification is incomplete and does not provide an adequate basis to conclude that ‘Adrafinil ...
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Chemical structure of modafinil.. This page lists chemical compounds similar to modafinil, known as modafinil analogues and derivatives.These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way (atypical dopamine reuptake inhibitor or DRI).
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In order to obtain a prescription for modafinil, a patient must have a valid medical reason for using the drug, such as narcolepsy or obstructive sleep apnea. Additionally, the prescription must be written by a licensed physician and filled at a licensed pharmacy. The use of modafinil for non-medical purposes, such as with the aim to improve ...
Flmodafinil is a selective dopamine reuptake inhibitor (DRI). [2] [8] [10] Its affinity (K i) for the DAT is 4,090 nM. [10]At the serotonin transporter (SERT), its affinity (K i) was 48,700 nM (12-fold lower than for the DAT), and it had negligible affinity for the sigma σ 1 receptor (K i > 100,000 nM). [10]
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