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Hyperchloremia is an electrolyte disturbance in which there is an elevated level of chloride ions in the blood. [1] The normal serum range for chloride is 96 to 106 mEq/L , [ 2 ] therefore chloride levels at or above 110 mEq/L usually indicate kidney dysfunction as it is a regulator of chloride concentration. [ 3 ]
Severity of symptoms is directly correlated with severity of hyponatremia and rapidness of onset. [3] General symptoms include loss of appetite, nausea, vomiting, confusion, agitation, and weakness. [14] [3] More concerning symptoms involve the central nervous system and include seizures, coma, and death due to brain herniation.
Nature Reviews Endocrinology is a monthly peer-reviewed medical journal published by Nature Portfolio. It covers all aspects of endocrinology . The journal was established in 2005 as Nature Clinical Practice Endocrinology & Metabolism and obtained its current title in April 2009. [ 1 ]
Analysis of accuracy has shown promise in DXplain and similar clinical decision support systems. In a preliminary trial investigation of 46 benchmark cases with a variety of diseases and clinical manifestations, the ranked differential diagnoses generated by DXplain were shown to be in alignment with a panel of five board-certified physicians ...
The Institute for Clinical and Economic Review (ICER) is a Boston-based independent nonprofit organization that seeks to place a value on medical care by providing comprehensive clinical and cost-effectiveness analyses of treatments, tests, and procedures. [1] ICER was founded in about 2005 by physician-researcher Steven D. Pearson. [1]
Institut de recherches cliniques de Montréal (IRCM), (also known, in English, as Montreal Clinical Research Institute), is a medical research institute affiliated with Université de Montréal. Its work focuses mainly on cellular biology, molecular biology, genetics, developmental biology, and proteomics. Its aim is to understand the causes of ...
Severe symptoms include confusion, muscle twitching, and bleeding in or around the brain. [ 1 ] [ 2 ] Normal serum sodium levels are 135–145 mmol/L (135–145 mEq/L ). [ 5 ] Hypernatremia is generally defined as a serum sodium level of more than 145 mmol/L. [ 3 ] Severe symptoms typically only occur when levels are above 160 mmol/L. [ 1 ]
Fanconi syndrome or Fanconi's syndrome (English: / f ɑː n ˈ k oʊ n i /, / f æ n-/) is a syndrome of inadequate reabsorption in the proximal renal tubules [1] of the kidney.The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. [2]