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Lindane, also known as gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC), [3] is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies.
Permethrin is a medication and an insecticide. [6] [7] As a medication, it is used to treat scabies and lice. [8]It is applied to the skin as a cream or lotion. [6] As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them.
Sulfiram or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies. [1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate. Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa (as monotherapy).
Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Scabies is caused by infection with the female mite Sarcoptes scabiei var. hominis, an ectoparasite. [3] The mites burrow into the skin to live and deposit eggs. [3] The symptoms of scabies are due to an allergic reaction to the mites. [2] Often, only between 10 and 15 mites are involved in an infection. [2]
Whereas the availability and nonproprietary nature of tea tree oil would make it – if proved effective – particularly well-suited to a disease such as scabies that affects poor people disproportionately, those same characteristics diminish corporate interest in its development and validation. [8]