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In medicine, ROC analysis has been extensively used in the evaluation of diagnostic tests. [57] [58] ROC curves are also used extensively in epidemiology and medical research and are frequently mentioned in conjunction with evidence-based medicine. In radiology, ROC analysis is a common technique to evaluate new radiology techniques. [59]
An image of different ROC curves is shown in Figure 1. ROC curves provide a simple visual method for one to determine the boundary limit (or the separation threshold) of a biomarker or a combination of biomarkers for the optimal combination of sensitivity and specificity. The AUC (area under the curve) of the ROC curve reflects the overall ...
There are different definitions within laboratory quality control, wherein "analytical sensitivity" is defined as the smallest amount of substance in a sample that can accurately be measured by an assay (synonymously to detection limit), and "analytical specificity" is defined as the ability of an assay to measure one particular organism or ...
The x- and y-axes are scaled non-linearly by their standard normal deviates (or just by logarithmic transformation), yielding tradeoff curves that are more linear than ROC curves, and use most of the image area to highlight the differences of importance in the critical operating region.
An example of ROC curve and the area under the curve (AUC). The area under the ROC curve (AUC) [1] [2] is often used to summarize in a single number the diagnostic ability of the classifier. The AUC is simply defined as the area of the ROC space that lies below the ROC curve. However, in the ROC space there are regions where the values of FPR ...
Example decision curve analysis graph with two predictors. A decision curve analysis graph is drawn by plotting threshold probability on the horizontal axis and net benefit on the vertical axis, illustrating the trade-offs between benefit (true positives) and harm (false positives) as the threshold probability (preference) is varied across a range of reasonable threshold probabilities.
For example, one could focus on the region of the curve with low false positive rate, which is often of prime interest for population screening tests. [17] Another common approach for classification problems in which P ≪ N (common in bioinformatics applications) is to use a logarithmic scale for the x-axis.
Interpretation [ edit ] The diagnostic odds ratio ranges from zero to infinity, although for useful tests it is greater than one, and higher diagnostic odds ratios are indicative of better test performance. [ 1 ]