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Dextran has yet to be approved for any clinical uses in drug delivery due to a wide variety of limitations including heterogeneity, undesirable side effects, and unknown biological pathways. Changes in the molecular weight of dextran have been shown to alter biological activity, indicating a need for separation and purification processes to ...
Dextran sulphate sodium (DSS), or dextran sodium sulphate (or any of the former with "sulfate") is a synthetic sulphated polysaccharide with anticoagulant activity used in immunological research to induce colitis. [1] [2] Dextran polymer molecules with a molecular weight of 36–50 kDa are frequently used to this end. [2]
An uncommon but significant complication of dextran osmotic effect is acute kidney injury. [15] The pathogenesis of this kidney failure is the subject of many debates with direct toxic effect on tubules and glomerulus versus intraluminal hyperviscosity being some of the proposed mechanisms.
In this process, a ligand is immobilized on the dextran surface of the SPR crystal. Through a microflow system, a solution with the analyte is injected over the ligand-covered surface. The binding of the analyte to the ligand causes an increase in the SPR signal (expressed in response units, RU).
Dextran 1 is composed of a small fraction (1 kilodalton) of the entire dextran complex. This is enough to bind anti-dextran antibodies but insufficient to result in the formation of immune complexes and resultant immune responses. Thereby, dextran 1 binds up antibodies towards dextran without causing the immune response, leaving less antibodies ...
Sean Duffy, U.S. Transportation secretary nominee arrives for a meeting with Wyoming Sen. Cynthia Lummis, R-Wyo., on Capitol Hill on Dec. 11, 2024, in Washington, D.C.
S. mutans uses the enzyme glucansucrase to convert sucrose into a sticky, extracellular, dextran-based polysaccharide that allows them to cohere, forming plaque. S. mutans produces dextran via the enzyme dextransucrase (a hexosyltransferase) using sucrose as a substrate in the following reaction: n sucrose → (glucose) n + n fructose
First is just a little bit of a clarification on the medium-term guidance. So you talked about 50 to 100 basis points of average margin expansion per year. You're guiding to over 100 here in 2025 ...