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Upon heating, cannabinoid acids decarboxylate to give their psychoactive cannabinoid. For example, Delta-9-tetrahydrocannabinol (THC) is the main psychoactive compound found in cannabis and is responsible for the "high" feeling when consumed. However, cannabis does not naturally contain significant amounts of THC.
[1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoactive compound in cannabis. [ 3 ] [ 4 ] Cannabidiol (CBD) is also a major constituent of temperate cannabis plants and a minor constituent in tropical varieties. [ 5 ]
Even at room temperature, trace amounts of THC can be formed as a contaminant in CBD stored for long periods in the presence of moisture and carbon dioxide in the air, with storage under inert gas required to maintain analytically pure CBD. [15] Heat is required to decarboxylate the non-psychoactive phytocannabinoid THCA to its psychoactive ...
Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.
Any psychoactive cannabis, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. As defined by US federal law, non-psychoactive hemp (also commonly termed "industrial hemp"), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆ 9-tetrahydrocannabinol ...
CBD is a 5-HT 1A receptor agonist, which is under laboratory research to determine if it has an anxiolytic effect. [145] It is often claimed that sativa strains provide a more stimulating psychoactive high while indica strains are more sedating with a body high. [146] However, this is disputed by researchers. [147]
The entourage effect is a hypothesis that cannabis compounds other than tetrahydrocannabinol (THC) act synergistically with it to modulate the overall psychoactive effects of the plant. [ 1 ] [ 2 ] The effect has also been applied in the case of psilocybin mushrooms , with other compounds besides psilocybin having been hypothesized to also ...
There are 483 identifiable chemical constituents known to exist in the cannabis plant, [53] and at least 85 different cannabinoids have been isolated from the plant. [54] The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ 9-tetrahydrocannabinol (THC), but only THC is psychoactive. [55]