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Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes.A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration.
Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. Functional genomics make use of the vast data generated by genomic and transcriptomic projects (such as genome sequencing projects and RNA sequencing ).
The mining process relies on a huge amount of data (represented by DNA sequences and annotations) accessible in genomic databases. By applying data mining algorithms , the data can be used to generate new knowledge in several areas of medicinal chemistry , [ 2 ] [ 3 ] such as discovering novel natural products .
Overall, the application of Hi-C and its variants in cancer research provides unique insight into the molecular underpinnings of the driving factors of cell abnormality. [23] [80] [81] It can help explain biological phenomena (high MYC expression in T-ALL) and help aid drug development to target mechanisms unique to cancerous cells. [23] [80] [81]
Workflow for DNA nanoball sequencing [1]. DNA nanoball sequencing is a high throughput sequencing technology that is used to determine the entire genomic sequence of an organism.
Neurogenomics: Study of genetic influences on the development and function of the nervous system. Pangenomics: Study of the entire collection of genes or genomes found within a given species. [14] Personal genomics: Branch of genomics concerned with the sequencing and analysis of the genome of an individual. Once the genotypes are known, the ...
This process greatly increases the number of SNPs that can be tested for association, increases the power of the study, and facilitates meta-analysis of GWAS across distinct cohorts. Genotype imputation is carried out by statistical methods that impute genotypic data to a set of reference panel of haplotypes, which typically have been densely ...
Computational genomics refers to the use of computational and statistical analysis to decipher biology from genome sequences and related data, [1] including both DNA and RNA sequence as well as other "post-genomic" data (i.e., experimental data obtained with technologies that require the genome sequence, such as genomic DNA microarrays). These ...