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In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel . Vesicles are essential for propagating nerve impulses between neurons and are constantly recreated by the cell .
Acetylcholine was the first neurotransmitter discovered in the peripheral and central nervous systems. It activates skeletal muscles in the somatic nervous system and may either excite or inhibit internal organs in the autonomic system. [17] It is main neurotransmitter at the neuromuscular junction connecting motor
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. [1] It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. [2] Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy.
In a resting individual, a specific region of the globus pallidus, the internal globus pallidus (GPi), and a part of the substantia nigra, the pars reticulata (SNpr), send spontaneous inhibitory signals to the ventral lateral nucleus (VL) of the thalamus, through the release of GABA, an inhibitory neurotransmitter. [3]
In addition, a synapse serves as a junction where both the transmission and processing of information occur, making it a vital means of communication between neurons. [ 11 ] At the synapse, the plasma membrane of the signal-passing neuron (the presynaptic neuron) comes into close apposition with the membrane of the target ( postsynaptic ) cell.
The neurotransmitter binds to chemical receptor molecules located in the membrane of another neuron, the postsynaptic neuron, on the opposite side of the synaptic cleft. Chemical synapses are biological junctions through which neurons ' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands .
A diagram of the proteins found in the active zone. The active zone is present in all chemical synapses examined so far and is present in all animal species. The active zones examined so far have at least two features in common, they all have protein dense material that project from the membrane and tethers synaptic vesicles close to the membrane and they have long filamentous projections ...
The neuromuscular junction (NMJ) is the most well-characterized synapse in that it provides a simple and accessible structure that allows for easy manipulation and observation. The synapse itself is composed of three cells: the motor neuron , the myofiber , and the Schwann cell .