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Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. [1] A biological target , also known as the site of action, can be binding proteins, ion channels , DNA , or a variety of other receptors.
Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12]
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It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
This is a list of films and television programs dubbed into indigenous languages. Indigenous language dubs are often made to promote language revitalisation and usage of the language. The number of films and television programs being dubbed into indigenous languages is growing, particularly in Australia, Canada, New Zealand and the United States.
He has provided voices for English-language versions of Japanese anime series and video games. His most notable roles include Gendo Ikari in the Rebuild of Evangelion films, Sir Crocodile in the Funimation dub of One Piece, Lord Death in Soul Eater, Van Hohenheim in Fullmetal Alchemist: Brotherhood, and All for One in My Hero Academia.
The English dub of the first season is available on Crunchyroll, with the English voice cast reprising their roles. [30] Crunchyroll and Funimation released the first season on Blu-ray and DVD on May 9, 2017, with an English dub. [31] [32] Madman Entertainment will import Funimation's release into Australia and New Zealand. [33]