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If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...
It also is a marker of cells from the monocyte/macrophage lineage. [8] CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. [9] [10] The receptor was discovered in 1987. [11]
In contrast to neoplastic mantle cells (which are negative for CD23), the resting cells of physiologic mantle zone express CD23. Paradoxically, Lymphomas arising from the mantle zone are generally negative for CD23, while most B-cell chronic lymphomocytic leukaemias are positive, allowing immunohistochemistry to distinguish these conditions ...
Today CD133 is the most commonly used marker for isolation of cancer stem cell (CSC) population from different tumors, mainly from various gliomas and carcinomas. [16] Initial studies that showed ability of CD133-positive population to efficiently propagate tumor when injected into immune-compromised mice firstly were performed on brain tumors.
CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.
596 12043 Ensembl ENSG00000171791 ENSMUSG00000057329 UniProt P10415 P10417 RefSeq (mRNA) NM_000633 NM_000657 NM_009741 NM_177410 RefSeq (protein) NP_000624 NP_000648 NP_033871 NP_803129 Location (UCSC) Chr 18: 63.12 – 63.32 Mb Chr 1: 106.47 – 106.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 ...
Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation. [6] The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. [7] Alternative splicing results in two transcript variants encoding different ...
Cellular immunity protects the body through: T-cell mediated immunity or T-cell immunity: activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;