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Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. [1] Dopamine receptors are therefore common drug targets. Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting ...
A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and have been used in treating schizophrenia , bipolar disorder , and stimulant psychosis . [ 1 ]
The side effects are predominantly collected from studies of Parkinson's disease, where dopamine agonists are commonly used as a first-line treatment with levodopa. [ 16 ] Dopamine agonists are divided into two subgroups or drug classes, first-generation and newer agents.
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
This results in increased extracellular concentrations of dopamine and increase in dopaminergic neurotransmission. [1] DRIs are used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects, and in the treatment of obesity and binge eating disorder for their appetite suppressant effects.
Common side effects include worsening kidney function, an irregular heartbeat, chest pain, vomiting, headache, or anxiety. [4] If it enters into the soft tissue around the vein local tissue death may occur. [4] The medication phentolamine can be given to try to decrease this risk. [4]
Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used antidepressants in 2017, according to the ...
Amantadine has dopaminergic effects through uncertain mechanisms of action. [24] [25] It is structurally related to other adamantanes like bromantane and rimantadine, which also have dopaminergic actions. [26] Bromantane can upregulate tyrosine hydroxylase (TH) and thereby increase dopamine production and this might be involved in its ...