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Transdermal estradiol has less-pronounced effects on these proteins and, in contrast to oral estradiol, reduces triglycerides. [1] Through these effects, both oral and transdermal estrogens can protect against atherosclerosis and coronary heart disease in menopausal women with intact arterial endothelium that is without severe lesions .
An estrogen patch, or oestrogen patch, is a transdermal delivery system for estrogens such as estradiol and ethinylestradiol which can be used in menopausal hormone therapy, feminizing hormone therapy for transgender women, hormonal birth control, and other uses. [1] Transdermal preparations of estrogen are metabolized differently than oral ...
The first transdermal estradiol gel, a hydroalcoholic gel known as EstroGel, was initially described in 1980 and was introduced in Europe around 1981. [223] Transdermal estradiol gel did not become available in the United States until 2004, when EstroGel was introduced in this country as well. [223]
Estradiol only recommended for use for the shortest period of time and at the lowest effective dose due to its adverse-effects profile. [29] There is the potential for a range of adverse effects in breasts , skin, eyes, cardiovascular , gastrointestinal , genitourinary or central nervous systems .
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Available transdermal estradiol patches in the United States [1] [2] [a] Brand name Dose (µg/day) DOA (d) Size [b] [c] (cm 2) Levels (pg/mL) Intro. Alora [3] [4] 25, 50, 75, 100 3–4 9, 18, 27, 36 43–144 1996 Climara [d] [5] [6] 25, 37.5, 50, 60, 75, 100 7 6.5, 9.375, 12.5, 15, 18.75, 25 17–174 1994 Climara Pro [e] [7] [8] E2 (45)
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