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Ganciclovir is commonly associated with a range of serious haematological adverse effects. Common adverse drug reactions (≥1% of patients) include: granulocytopenia, neutropenia, anaemia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, seizures, pain and phlebitis at injection site ...
The original edition, known as the Toxic Substances List was published on June 28, 1971, and included toxicological data for approximately 5,000 chemicals. The name changed later to its current name Registry of Toxic Effects of Chemical Substances. In January 2001 the database contained 152,970 chemicals.
The NIOSH occupational exposure banding process has been created to provide a reliable approximation of a safe exposure level for potentially hazardous and unregulated chemicals in the workplace. [6] Occupational exposure banding uses limited chemical toxicity data to group chemicals into one of five bands. Occupational exposure bands: [7]
It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act [ 1 ] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.
Amprenavir pro-drug: 2003 (FDA), 2004 Foscarnet: Herpes: Pyrophosphate analogue DNA polymerase inhibitor: 1991 Ganciclovir (Cytovene) [9] Cytomegalovirus (CMV) [10] Competitive nucleoside analogue dGTP inhibitor 1988 Ibacitabine: Herpes labialis: Ibalizumab (Trogarzo) [11] HIV Entry inhibitor 2018 Idoxuridine: Herpes: dU analogue inhibitor 1962 ...
Genotoxicity might involve carcinogenicity, the ability to cause cancer in animal models, humans or both; teratogenicity, which is the ability to cause defects on fetal development or fetal malformation; and lastly hazardous drugs are known to have the potential to cause fertility impairment, which is a major concern for most clinicians. [1]
ATSDR is an agency within the US Department of Health and Human Services concerned with the effects of hazardous substances on human health. ATSDR is charged with assessing the presence and nature of health hazards at specific Superfund sites, as well as helping prevent or reduce further exposure and the illnesses that can result from such exposures. [7]
An occupational exposure limit is an upper limit on the acceptable concentration of a hazardous substance in workplace air for a particular material or class of materials. It is typically set by competent national authorities and enforced by legislation to protect occupational safety and health.