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The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center.
An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic gene expression. [1] [2] Translation of the uORF typically inhibits downstream expression of the primary ORF. However, in some genes such as yeast GCN4, translation of specific uORFs may ...
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base ...
The eukaryotic 5′ UTR also contains cis-acting regulatory elements called upstream open reading frames (uORFs) and upstream AUGs (uAUGs) and termination codons, which have a great impact on the regulation of translation . Unlike prokaryotes, 5′ UTRs can harbor introns in eukaryotes. In humans, ~35% of all genes harbor introns within the 5 ...
n/a Ensembl ENSG00000211689 n/a UniProt Q0VGM3 n/a RefSeq (mRNA) NM_001003799 NM_001003806 n/a RefSeq (protein) NP_001003806.1 n/a Location (UCSC) Chr 7: 38.26 – 38.27 Mb n/a PubMed search n/a Wikidata View/Edit Human TCR gamma alternate reading frame protein, also known as TARP, is a human gene. In some non- lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed ...
When it comes to nutrition, celebs take tips from the experts too! Case in point: Jessica Alba went to nutritionist Kelly LeVeque for advice due to feeling sluggish, rundown and perpetually ...