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Osteoarthritis (OA) is caused by the wear and tear damage to the joint's cartilage. The compelling pharmacological recommendations for the treatment of OA are oral NSAIDs, topical NSAIDs (for hands and knees), and I-A steroids. Other conditionally recommended therapies include Acetaminophen, Tramadol, Duloxetine, Chondroitin, and Topical Capsaicin.
A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression of osteoarthritis. [1] Since the main hallmark of osteoarthritis is cartilage loss, a typical DMOAD would prevent the loss of cartilage and potentially regenerate it.
The Osteoarthritis Research Society International (OARSI) is a non-profit scientific organization. [1] The mission of OARSI is to promote and advance research for the prevention and treatment of osteoarthritis .
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
According to our research, the Osteoarthritis Unloader Knee Brace from BraceAbility is a good option. It works by placing adjustable, padded pressure on one side of the knee to “unload” the ...
A 2017 review described the evidence as moderate for knee osteoarthritis. [15] A 2016 review found benefit but there was a moderate degree of variability between trials and risk of bias. [16] In 2019, the American College of Rheumatology recommended against prolotherapy for knee osteoarthritis. [17]
On June 1, 2020, Antibe announced positive results for Otenaproxesul in its final Phase 2 trial – a dose ranging, efficacy study. [12] The company's second drug, an opioid-replacement for post-surgical pain, is expected to start clinical trials in late 2023. [13] On November 12, 2020, Antibe Therapeutics has moved to the TSX.
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