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Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. [4] There are several non-specific and vague signs and symptoms associated with amyloidosis. [5] These include fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing. [5]
[2] [3] It may be a localised or generalised disease. [2] Examples of locations where histiocytosis may occur include the lungs, pleura, stomach, kidney, bone marrow, thyroid, thymus, and parotid gland. [2] The disease is described as generalised if two or more unrelated sites are involved. [2]
One such stain is Congo Red, which binds specifically to the amyloid deposit and can be characterized by various lighting methods. [7] Under polarized light, the amyloid deposits while show pathognomonic apple green birefringence, and under plain light the deposits will appear a light salmon pink color. [ 7 ]
A mysterious illness, which the Africa Centers for Disease Control and Prevention is calling "disease X," has killed at least 31 people — mostly children — in the remote Panzi region of the ...
Bone marrow failure in both children and adults can be either inherited or acquired. Inherited bone marrow failure is often the cause in young children, while older children and adults may acquire the disease later in life. [3] Acquired bone marrow failure may be due to aplastic anemia [4] or myelodysplastic syndrome.
Dysplasia can affect all three lineages seen in the bone marrow. The best way to diagnose dysplasia is by morphology and special stains used on the bone marrow aspirate and peripheral blood smear. Dysplasia in the myeloid series is defined by: Granulocytic series [citation needed]:
Waldenström's macroglobulinemia (also known as lymphoplasmacytic lymphoma) is a lymphoproliferative disease that involves an abnormal increase of lymphocytes within the bone marrow, creasing disruption of normal red blood cell production. [76] Nodal marginal zone B cell lymphoma: Splenic marginal zone lymphoma
The liver is then used as the main hematopoietic organ of the embryo until near birth, where it is then taken over by the bone marrow. [5] Most red blood cells are released into the blood as reticulocytes. Polychromasia occurs when the immature reticulocytes of the bone marrow are released, resulting in a grayish blue color of the cells.