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Coxsackie B is a group of six serotypes of coxsackievirus (CVB1-CVB6), a pathogenic enterovirus, that trigger illnesses ranging from a mild febrile rash to full-fledged pericarditis and myocarditis (coxsackievirus-induced cardiomyopathy). [1] [2] The genome of Coxsackie B virus consists of approximately 7,400 base pairs. [3]
Coxsackieviruses are divided into group A and group B viruses based on early observations of their pathogenicity in neonatal mice. [1] Group A coxsackieviruses were noted to cause a flaccid paralysis (which was caused by generalized myositis) while group B coxsackieviruses were noted to cause a spastic paralysis (due to focal muscle injury and degeneration of neuronal tissue).
Coxsackie B viruses are found worldwide and can cause myocarditis (inflammation of the heart); pericarditis (inflammation of the sac surrounding the heart); meningitis (inflammation of the membranes that line the brain and spinal cord); and pancreatitis (inflammation of the pancreas). The Coxsackie B viruses are also reported to cause a spastic ...
Coxsackievirus B4 is one of the six serotypes found in Group B and is a positive sense, single-stranded, non-enveloped RNA virus. Its genome is linear and is 7,293 nucleotides in length with both a 5’ and 3’ untranslated region and encodes its own 3’ poly-A tail.
Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. [5] [6] [7] The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses.
Coxsackie B virus: Coxsackie B virus infection Enterovirus infection is diagnosed mainly via serological tests such as ELISA and from cell culture. There is no well-accepted treatment for the Coxsackie B group of viruses. Under research [10] PRNP: Creutzfeldt–Jakob disease (CJD) No Crimean-Congo hemorrhagic fever virus Crimean-Congo ...
Diabetes mellitus type 1: Diabetes mellitus type 1 is associated with viral species from the enterovirus genus, [53] [54] specifically echovirus 4 [55] and Coxsackie B virus (the latter it is thought may infect and destroy the insulin producing beta-cells in the pancreas and also damage these cells via indirect autoimmune mechanisms).
Bornholm disease, also known as epidemic pleurodynia, [1] is a condition characterized by myositis of the abdomen or chest caused by the Coxsackie B virus or other viruses. [2] The myositis manifests as an intermittent stabbing pain in the musculature that is seen primarily in children and young adults. [3]