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There is a slight increase in dose proportionality in terms of peak and area-under-the-curve levels of THC with increasing oral doses over a range of 2.5 to 10 mg. [22] A high-fat meal delays time to peak concentrations of oral THC by 4 hours on average and increases area-under-the-curve exposure by 2.9-fold, but peak concentrations are not ...
Nabiximols [2] sold under the brand name Sativex, is a specific Cannabis extract that was approved in 2010 as a botanical drug in the United Kingdom. Nabiximols is sold as a mouth spray intended to alleviate neuropathic pain , spasticity , overactive bladder , and other symptoms of multiple sclerosis ; it was developed by the UK company GW ...
Cannabis material can be leached in high-proof spirits (often grain alcohol) to create a "Green Dragon". Cannabis can also be consumed as a cannabis tea and many other beverages. Although THC is lipophilic and only slightly water soluble (with a solubility of 2.8 mg per liter), [13] enough THC can be dissolved to make a mildly psychoactive tea ...
Another problem, despite the dosage written on a brand’s packaging, is that the actual amount of THC varies from product to product. This makes it even harder to pin down how much is too much.
In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index, [21] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation. [22]
Effective dose: It is the minimum dose or concentration of a drug that produces a biological response in 50% of a population being studied. Median lethal dose: For either drugs or toxins, it is a toxic unit that measures the minimum dose that causes death (lethal dose) in 50% of cases.
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Cannabis concentrate, also called marijuana concentrate, marijuana extract, or cannabis extract, is a tetrahydrocannabinol (THC) and/or cannabidiol (CBD) concentrated mass. Cannabis concentrates contain high THC levels that range from 40% to over 90%, [ 1 ] [ 2 ] stronger in THC content than high-grade marijuana, which normally measures around ...