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  2. Nucleoside-modified messenger RNA - Wikipedia

    en.wikipedia.org/wiki/Nucleoside-modified...

    A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues.

  3. mRNA vaccine - Wikipedia

    en.wikipedia.org/wiki/MRNA_vaccine

    Pfizer–BioNTech's BNT162b2 mRNA vaccine has to be kept between −80 and −60 °C (−112 and −76 °F). [86] [87] Moderna says their mRNA-1273 vaccine can be stored between −25 and −15 °C (−13 and 5 °F), [88] which is comparable to a home freezer, [87] and that it remains stable between 2 and 8 °C (36 and 46 °F) for up to 30 days.

  4. Genetic vaccine - Wikipedia

    en.wikipedia.org/wiki/Genetic_vaccine

    In 1995, Robert Conry and colleagues described that a humoral immune response was also elicited after vaccination with an RNA vaccine. [13] [11] While DNA vaccines were more frequently researched in the early years due to their ease of production, low cost, and high stability to degrading enzymes, but sometimes produced low vaccine responses ...

  5. History of COVID-19 vaccine development - Wikipedia

    en.wikipedia.org/wiki/History_of_COVID-19...

    All RMPs for COVID‑19 vaccines will be published on the EMA's website. [136] The EMA published guidance for developers of potential COVID‑19 vaccines on the clinical evidence to include in marketing authorization applications. [137] In November 2020, the CHMP started a rolling review of the Moderna vaccine for COVID‑19 known as mRNA-1273 ...

  6. Moderna COVID-19 vaccine - Wikipedia

    en.wikipedia.org/wiki/Moderna_COVID-19_vaccine

    The Moderna COVID‑19 vaccine, sold under the brand name Spikevax, is a COVID-19 vaccine developed by the American company Moderna, the United States National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA).

  7. COVID-19 vaccine - Wikipedia

    en.wikipedia.org/wiki/COVID-19_vaccine

    How COVID‑19 vaccines work. The video shows the process of vaccination, from injection with RNA or viral vector vaccines, to uptake and translation, and on to immune system stimulation and effect. Part of a series on the COVID-19 pandemic Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom. COVID-19 (disease) SARS-CoV-2 (virus) Cases Deaths ...

  8. ORF1ab - Wikipedia

    en.wikipedia.org/wiki/ORF1ab

    Throughout the COVID-19 pandemic, the genome of SARS-CoV-2 viruses has been sequenced many times, resulting in identification of thousands of distinct variants. In a World Health Organization analysis from July 2020, ORF1ab was the most frequently mutated gene, followed by the S gene encoding the spike protein .

  9. Transcriptome - Wikipedia

    en.wikipedia.org/wiki/Transcriptome

    The term transcriptome is a portmanteau of the words transcript and genome; it is associated with the process of transcript production during the biological process of transcription. The early stages of transcriptome annotations began with cDNA libraries published in the 1980s. Subsequently, the advent of high-throughput technology led to ...