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Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
One of the important questions in sleep research is clearly defining the sleep state. This problem arises because sleep was traditionally defined as a state of consciousness and not as a physiological state, [14] [15] thus there was no clear definition of what minimum set of events constitute sleep and distinguish it from other states of partial or no consciousness.
Humans may suffer from various sleep disorders, including dyssomnias, such as insomnia, hypersomnia, narcolepsy, and sleep apnea; parasomnias, such as sleepwalking and rapid eye movement sleep behavior disorder; bruxism; and circadian rhythm sleep disorders. The use of artificial light has substantially altered humanity's sleep patterns. [10]
Collectively, hormones regulate many physiological processes. The neuroendocrine system is the mechanism by which the hypothalamus maintains homeostasis , regulating reproduction , metabolism , eating and drinking behaviour, energy utilization , osmolarity and blood pressure .
[1] [24] [25] Orexin neurons in the posterior lateral hypothalamus potentiate neurons in the ascending arousal system and help stabilize the brain in the waking state (and consolidated wakefulness, which builds up homeostatic sleep drive, helps stabilize the brain during later sleep). The loss of orexin neurons in the disorder narcolepsy ...
Sleep deprivation is a significant societal problem. It is estimated that around 35.2% of all adults in the US sleep less than 7 hours. [3] Lifestyle choices, health conditions, and the use of stimulants are examples of some of the causes that underlie sleep deprivation in humans. Sleep deprivation is known to cause metabolic changes, such as ...
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