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Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [5] [6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules.
In humans, 23 members of the FGF family have been identified, all of which are structurally related signaling molecules: [2] [3] [4] Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor.
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. [5] FGFR3 has also been designated as CD333 ( cluster of differentiation 333). The gene, which is located on chromosome 4 , location p16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys.
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. [ 5 ] [ 6 ] FGFR2 is a receptor for fibroblast growth factor .
FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 ( FGFR3 ) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.
1. Nentwich O, Dingwell KS, Nordheim A, Smith JC. 2009. Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1. Dev Bio 336:313-26. 2. Kimelman D. 2006. Mesoderm induction: from caps to chips. Nature Rev Genet 7:360-72. 3. Heasman J. 1997. Patterning the Xenopus blastula. Development 124:4179-91. 4. Heasman J. 2006.