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The dose used by Palmer and colleagues was dramatically higher than that used in humans, the equivalent of about 20 grams per day. [47] In humans, much lower dosages (600 mg per day) have been observed to counteract some age-related decline in the hypoxic ventilatory response as tested by inducing prolonged hypoxia .
It is approved by the U.S. Food and Drug Administration for the treatment or prevention of vitamin deficiencies. [ 1 ] "Cerefolin NAC" contains L-methylfolate (as Metafolin) 5.6 mg, methylcobalamin 2 mg, N-acetylcysteine 600 mg. [ 2 ]
Proposed revision: "Acetylcysteine, also known as N-acetylcysteine (NAC) or N-acetyl-L-cysteine, is a mucolytic compound that is used as a medication for the treatment of paracetamol (acetaminophen) overdose and to loosen excessively thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease. [1] "
[20] [74] Oral acetylcysteine is given as a 140 mg/kg loading dose followed by 70 mg/kg every four hours for 17 more doses, and if the patient vomits within 1 hour of dose, the dose must be repeated. [75] [76] Oral acetylcysteine may be poorly tolerated due to its unpleasant taste, odor, and its tendency to cause nausea and vomiting. [72]
A systematic review and meta-analysis of 5 studies found that N-acetylcysteine reduces depressive symptoms more than placebo and has good tolerability. [125] N-acetylecysteine may exert its benefits by replenishing the chief cellular antioxidant, glutathione, thus modulating glutamatergic, neurotropic and inflammatory pathways. [126]
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