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The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous cavities and internal organs. The main purpose of these cells is to produce a lubricating fluid that is released between layers, [4] providing a slippery, non-adhesive, and protective surface to facilitate intracoelomic ...
Schematic diagram of an organ invaginating into a serous cavity. The pericardial cavity (surrounding the heart), pleural cavity (surrounding the lungs) and peritoneal cavity (surrounding most organs of the abdomen) are the three serous cavities within the human body. While serous membranes have a lubricative role to play in all three cavities ...
Mesothelin is a 40 kDa protein that is expressed in mesothelial cells. [7] The protein was first identified by its reactivity with monoclonal antibody K1. [8] Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named ...
Every cell consists of cytoplasm enclosed within a membrane; many cells contain organelles, each with a specific function. The term comes from the Latin word cellula meaning 'small room'. Most cells are only visible under a microscope. Cells emerged on Earth about 4 billion years ago. All cells are capable of replication, protein synthesis, and ...
The basement membrane acts as a mechanical barrier, preventing malignant cells from invading the deeper tissues. [7] Early stages of malignancy that are thus limited to the epithelial layer by the basement membrane are called carcinoma in situ. The basement membrane is also essential for angiogenesis (development of new blood vessels).
The cells here may possess microvilli for maximizing the surface area for absorption, and these microvilli may form a brush border. Other cells may be ciliated to move mucus in the function of mucociliary clearance. Other ciliated cells are found in the fallopian tubes, the uterus and central canal of the spinal cord.
The surface of the ovaries is covered with a membrane consisting of a lining of simple cuboidal-to-columnar shaped mesothelium, [7] called the germinal epithelium. Micrograph of the ovarian cortex from a rhesus monkey showing several round follicles embedded in a matrix of stromal cells. A secondary follicle sectioned through the nucleus of an ...
Each pleura comprises a superficial serosa made of a simple monolayer of flat (squamous) or cuboidal mesothelial cells with microvilli up to 6 μm (0.00024 in) long. The mesothelium is without basement membrane, and supported by a well-vascularized underlying loose connective tissue containing two poorly defined layers of elastin-rich