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A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.
The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex [6] (Fig. 3).) Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations [7] They have two defining features: their long-term ability to self-renew and ...
The Stephenson Cancer Center, formerly known as the OU Cancer Institute, is located on the University of Oklahoma Health Sciences Center campus in Oklahoma City. Under the guidance of Robert Mannel, MD, Director, the mission of the Cancer Center is to promote and support cancer research, education, care, and patient support for Oklahomans and ...
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Research using both hematopoietic adult stem cells and embryonic stem cells has provided insight into the possible mechanisms and methods of treatment for many of these ailments. [ 56 ] Fully mature human red blood cells may be generated ex vivo by hematopoietic stem cells (HSCs), which are precursors of red blood cells.
Pluripotent adult stem cells are rare and generally small in number, but they can be found in umbilical cord blood and other tissues. [48] Bone marrow is a rich source of adult stem cells, [49] which have been used in treating several conditions including liver cirrhosis, [50] chronic limb ischemia [51] and endstage heart failure. [52]
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