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The outline of the classical Hi-C workflow is as follows: cells are cross-linked with formaldehyde; chromatin is digested with a restriction enzyme that generates a 5’ overhang; the 5’ overhang is filled with biotinylated bases and the resulting blunt-ended DNA is ligated. [1]
High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner.
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices".
In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage. It has been estimated that under physiological conditions 10,000 apurinic sites and 500 ...
Chromosome conformation capture techniques (often abbreviated to 3C technologies or 3C-based methods [1]) are a set of molecular biology methods used to analyze the spatial organization of chromatin in a cell.
High throughput cell biology has many definitions, but is most commonly defined by the search for active compounds in natural materials like in medicinal plants. This is also known as high throughput screening (HTS) and is how most drug discoveries are made today, many cancer drugs, antibiotics, or viral antagonists have been discovered using ...
HCI are found in stellar corona, in active galactic nuclei, in supernova remnants, and in accretion disks. Most of the visible matter found in the universe consists of highly charged ions. [ 1 ] High temperature plasmas used for nuclear fusion energy research also contain HCI generated by the plasma-wall interaction (see Tokamak ).
Human–computer information retrieval (HCIR) is the study and engineering of information retrieval techniques that bring human intelligence into the search process. It combines the fields of human-computer interaction (HCI) and information retrieval (IR) and creates systems that improve search by taking into account the human context, or through a multi-step search process that provides the ...