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16191 Ensembl ENSG00000113525 ENSMUSG00000036117 UniProt P05113 P04401 RefSeq (mRNA) NM_000879 NM_010558 RefSeq (protein) NP_000870 NP_034688 Location (UCSC) Chr 5: 132.54 – 132.56 Mb Chr 11: 53.61 – 53.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Function Through binding to the ...
The interleukin-5 receptor is a type I cytokine receptor.It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. [1] [2]The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the ...
FedRAMP is governed by different Executive Branch entities that collaborate to develop, manage, and operate the program. [8] These entities include: The Office of Management and Budget (OMB): The governing body that issued the FedRAMP policy memo, which defines the key requirements and capabilities of the program
Data de-duplication mechanism. High level [clarification needed] of scalability and cost effectiveness. ICFiles Secure File Share Storage. Proprietary license download client. High level security, SOC 2 TYPE II, ISO 27001,27017, 27018, CSA, PCI, HIPAA, CJIS, EU Model Clauses, on request private servers for FISMA and FedRAMP. IDrive
Interleukin 5 (IL5), also known as eosinophil differentiation factor (EDF), is a lineage-specific cytokine for eosinophilpoiesis. [ 17 ] [ 18 ] It regulates eosinophil growth and activation, [ 17 ] and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma. [ 18 ]
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5).
Reslizumab, sold under the brand names Cinqair and Cinqaero, is a humanized monoclonal antibody against human interleukin-5 (IL-5). [5] Reslizumab binds specifically to IL-5, a key cytokine responsible for the differentiation, maturation, recruitment and activation of human eosinophils.
It is a pro-inflammatory cytokine that shares similar biological effects to IL-12 and structural forms with the IL-1 family. Together with IL-12 it mediates cellular immunity. It binds to the IL-18Rα receptor. It is produced by monocytes, macrophages, osteoblasts, keratinocytes.
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