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2. Thymus transplantation - Wikipedia

   en.wikipedia.org/wiki/Thymus_transplantation

   Second, a thymus transplantation can cause a non-donor T cell-related GVHD because the recipients thymocytes would use the donor thymus cells as models when going through the negative selection to recognize self-antigens, and could therefore still mistake own structures in the rest of the body for being non-self. This is a rather indirect GVHD ...

3. Graft-versus-host disease - Wikipedia

   en.wikipedia.org/wiki/Graft-versus-host_disease

   Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). The ...

4. Transfusion-associated graft-versus-host disease - Wikipedia

   en.wikipedia.org/wiki/Transfusion-associated...

   The incidence of TA-GvHD in immunocompromised patients receiving blood transfusions is estimated to be 0.1–1.0%, and mortality around 80–90%. Mortality is higher in TA-GvHD than in GvHD associated with bone marrow transplantation , where the engrafted lymphoid cells in the bone marrow are of donor origin (in autotransplant) and therefore ...

5. Anti-thymocyte globulin - Wikipedia

   en.wikipedia.org/wiki/Anti-thymocyte_globulin

   The Canadian Blood and Marrow Transplant Group is currently conducting the first randomised trial in chronic graft versus host using an even lower dose of rabbit ATG (4.5 mg/kg) in an attempt to confirm these observations. The endpoint is the reduction in the proportion of patients with chronic graft versus host at 1 year, off ...

6. Thymoglobulin - Wikipedia

   en.wikipedia.org/wiki/Thymoglobulin

   Thymoglobulin is also an effective agent for preventing graft-vs.-host disease in patients receiving haematopoietic stem cell transplantation (HSCT). GVHD is a condition in which immune cells within the graft attack host cells and cause tissue damage. It is considered a major obstacle to successful HSCT. [1]

7. Thymoma-associated multiorgan autoimmunity - Wikipedia

   en.wikipedia.org/wiki/Thymoma-associated_multi...

   Thymoma is a common neoplasm arising from the thymus, the primary lymphoid organ where T cells become educated to distinguish "self" from "non self". In the setting of thymoma, abnormal thymic education occurs as a result of subtle differences in antigen processing. In TAMA these differences result in autoreactive T cells escaping from the thymus.