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Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production .
Firstly, some forms of endocrine therapy can be administered to block estrogen synthesis. In pre-menopausal women, this can be achieved through surgical ovarian ablation (by oophorectomy) or chemical ovarian suppression (using luteinizing hormone releasing hormone agonists, such as goserilin).
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
For women, a drop in estrogen can cause weight gain, particularly in the abdomen (aka menopause belly). For men, low testosterone is linked to an increase in fat mass. Men with obesity are more ...
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Image credits: Ludwig_Vista2 #7. Endometriosis (tissue from the womb) is not cancer. But it can send out cells that spread through your internal organs and grow, stick your guts together or block ...
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