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Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; ... RNA polymerase inhibitors (2 C, 5 P) S. Steroidogenesis inhibitors (19 C ...
Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation. Germ cell tumours, squamous cell carcinoma, pancreatic cancer, non-Hodgkin's, pleural sclerosing and Hodgkin's lymphoma. Pulmonary toxicity, hypersensitivity, scleroderma and Raynaud's phenomenon. Bortezomib: IV, SC
RNA polymerase 1 (also known as Pol I) is, in higher eukaryotes, the polymerase that only transcribes ribosomal RNA (but not 5S rRNA, which is synthesized by RNA polymerase III), a type of RNA that accounts for over 50% of the total RNA synthesized in a cell.
Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA inhibitors. [1] The antifungal flucytosine acts in a similar manner.
20019 Ensembl ENSG00000068654 ENSMUSG00000049553 UniProt O95602 O35134 RefSeq (mRNA) NM_015425 NM_009088 RefSeq (protein) NP_056240 NP_033114 Location (UCSC) Chr 2: 86.02 – 86.11 Mb Chr 6: 71.89 – 71.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. References ^ a b c GRCh38 ...
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [ 1 ] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins
PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.