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Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; ... RNA polymerase inhibitors (2 C, 5 P) S. Steroidogenesis inhibitors (19 C ...
Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation. Germ cell tumours, squamous cell carcinoma, pancreatic cancer, non-Hodgkin's, pleural sclerosing and Hodgkin's lymphoma. Pulmonary toxicity, hypersensitivity, scleroderma and Raynaud's phenomenon. Bortezomib: IV, SC
RNA polymerase 1 (also known as Pol I) is, in higher eukaryotes, the polymerase that only transcribes ribosomal RNA (but not 5S rRNA, which is synthesized by RNA polymerase III), a type of RNA that accounts for over 50% of the total RNA synthesized in a cell.
20019 Ensembl ENSG00000068654 ENSMUSG00000049553 UniProt O95602 O35134 RefSeq (mRNA) NM_015425 NM_009088 RefSeq (protein) NP_056240 NP_033114 Location (UCSC) Chr 2: 86.02 – 86.11 Mb Chr 6: 71.89 – 71.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. References ^ a b c GRCh38 ...
Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA inhibitors. [1] The antifungal flucytosine acts in a similar manner.
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [ 1 ] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.