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Schematic structure of an antibody–drug conjugate (ADC) Antibody–drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. [ 1 ] Unlike chemotherapy , ADCs are intended to target and kill tumor cells while sparing healthy cells.
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An ADC may also provide an isolated measurement such as an electronic device that converts an analog input voltage or current to a digital number representing the magnitude of the voltage or current. Typically the digital output is a two's complement binary number that is proportional to the input, but there are other possibilities.
In 2017, Pfizer reapplied for US and EU approval, based on a meta-analysis of prior trials and results of the ALFA-0701 clinical trial, an open-label Phase III trial in 280 older people with AML. [20] In September 2017, gemtuzumab ozogamicin was approved again for use in the United States [8] [28] and in the European Union. [7]
The case centers on Meta acquisition of Facebook's two former competitors—Instagram and WhatsApp. The FTC alleges that Meta holds monopolistic power in the US social networking market and seeks to force the company to divest from Instagram and WhatsApp to break up the conglomerate. The Federal Trade Commission said that Meta's actions prevent ...
Meta Platforms, Inc., [9] doing business as Meta, [10] and formerly named Facebook, Inc., and TheFacebook, Inc., [11] [12] is an American multinational technology conglomerate based in Menlo Park, California. The company owns and operates Facebook, Instagram, Threads, and WhatsApp, among other products and services. [13]
The Anti-Meta Fedipact (or just Fedipact) is a pledge signed by various administrators of fediverse instances regarding the moderation of content originating from Threads. [ 51 ] [ 52 ] Signatories believe that Meta will employ an "embrace, extend, and extinguish" strategy and become an existential threat to the fediverse, with many criticizing ...
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.