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Elagolix is used in the treatment of moderate to severe pain associated with endometriosis in premenopausal women. [1] Endometriosis is a condition in which the endometrium, the inner lining of the uterus, grows outside of the uterus into surrounding tissues and causes symptoms such as pelvic pain and infertility. [13]
However, due to high rates of side-effects with the drugs used at the time, sclerotherapy had been practically abandoned by 1894. [9] With the improvements in surgical techniques and anaesthetics over that time, stripping became the treatment of choice. Work continued on alternative sclerosants in the early 20th century.
The advantages of physical therapy techniques are decreased cost, absence of major side-effects, it does not interfere with fertility, and near-universal increase of sexual function. [176] Disadvantages are that there are no large or long-term studies of its use for treating pain or infertility related to endometriosis. [176]
A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
Side effects of relugolix include menstrual abnormalities, hot flashes, excessive sweating, headache, and decreased bone mineral density. [7] [1] Relugolix is a GnRH antagonist, or an antagonist of the gonadotropin-releasing hormone receptor. [1]
Endometriosis is estimated to occur in 7% to 10% of women, with an associated risk of infertility for between 30% and 50% of this population. [1] [2] [3] Endometriosis is commonly classified under the revised American Society for Reproductive Medicine system from minimal endometriosis to severe endometriosis. The therapy and management of ...
Common side effects include hot flashes, unstable mood, trouble sleeping, headaches, and pain at the site of injection. [10] Other side effects may include high blood sugar, allergic reactions, and problems with the pituitary gland. [10] Use during pregnancy may harm foetal development. [10]
More serious side effects include bone loss, blood clots, allergic reactions, and liver problems. [10] Use is not recommended during pregnancy as it may harm the baby . [ 10 ] MPA is an artificial progestogen , and as such activates the progesterone receptor , the biological target of progesterone . [ 4 ]