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Porphyria cutanea tarda is the most common subtype of porphyria. [1] The disease is named because it is a porphyria that often presents with skin manifestations later in life. The disorder results from low levels of the enzyme responsible for the fifth step in heme production.
Porphyria Cutanea Tarda (PCT): PCT is the most common form of porphyria, with an estimated prevalence of 1 to 2 cases per 10,000 individuals in the general population. It predominantly affects adults, with a higher prevalence in men than in women.
The Watson–Schwartz test is a screening test for diagnosing intermittent porphyria, although it might also become positive in porphyria cutanea tarda (a skin form of porphyria). In this method, porphobilinogen is detected by a color reaction with Ehrlich reagent and confirming that the color is not removed by chloroform.
The initial diagnosis of acute porphyria is confirmed by urinalysis, including the common method, the Watson-Schwartz test. Elevated urine porphobilinogen confirms diagnosis of AIP, hereditary coproporphyria (HCP), or variegate porphyria (VP).
Pseudoporphyria is a bullous photosensitivity that clinically and histologically mimics porphyria cutanea tarda. [2]: 524 The difference is that no abnormalities in urine or serum porphyrin is noted on laboratories.
Nearly all cases of porphyria cutanea tarda [18] exhibit blister formation on the skin within 2–4 days of light exposure. Variegate porphyria [ 19 ] and hereditary coproporphyria [ 20 ] can also exhibit symptoms of light-induced blisters.
Erythropoietic protoporphyria (or commonly called EPP) is a form of porphyria, which varies in severity and can be very painful.It arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the red blood cells (erythrocytes), plasma, skin, and liver. [2]
Porphyria cutanea tarda; Xeroderma pigmentosum; Diagnosis. There are several ways in which medical professional can diagnose photodermatoses. Usually a detailed ...
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