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Chagas is a potentially fatal neglected disease that affects between 8 and 13 million people worldwide. DNDi 's Time to Treat campaign is pushing for increased political interest in new treatments for Chagas disease, increased public awareness of the disease and treatment limitations and increased public and private investment in R&D.
Chagas disease can be prevented by avoiding insect bites through insecticide spraying, home improvement, bed nets, hygienic food, medical care, laboratory practices, and testing. [38] It can be diagnosed through a serological test, although the test is not very accurate. [18] Treatment is with medication, which may have severe side effects. [38]
Chagas was the son of José Justiniano das Chagas, a coffee farmer at Juiz de Fora in Minas Gerais, and Mariana Cândida Chagas (née Ribeiro de Castro), both of Portuguese descent. [2] His birth place is also recorded as Oliveira, his mother's hometown, [ 3 ] where the family spent half of their times.
Chagas' discovery brought him national and international renown, but in highlighting the inadequacies of the Brazilian government's response to the disease, Chagas attracted criticism to himself and to the disease that bore his name, stifling research on his discovery and likely frustrating his nomination for the Nobel Prize in 1921. [59] [62]
Chagas disease is caused by Trypanosoma cruzi and is mostly spread by Triatominae. It is endemic to 21 countries in Latin America. There are over 30,000 new cases per year and 12,000 deaths due to the disease. [143] Eradication efforts focus on the elimination of vector-borne transmission and the elimination of the vectors themselves. [143]
Émile Brumpt introduced the xenodiagnosis technique into parasitological research and extensively studied such diseases as bilharzia, Chagas disease, onchocerciasis and leishmaniasis. Medical professionals primarily use xenodiagnosis in determining the presence of a chronic infection of Trypanosoma cruzi (the flagellate that causes Chagas ...
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
In the 1940s fisherman Henrique Penna from the Rockefeller Foundation in Rio de Janeiro reported that he had discovered cases of leishmaniasis in Brazil's countryside. [1] The disease had not been previously detected in Brazil, and as a response, Carlos Chagas of the Oswaldo Cruz Institute organized a commission leishmaniasis to be headed by his son Evandro Chagas.