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Xylitol is poisonous to dogs. [8] Ingesting 100 milligrams of xylitol per kilogram of body weight (mg/kg bw) causes dogs to experience a dose-dependent insulin release; depending on the dose it can result in life-threatening hypoglycemia. Hypoglycemic symptoms of xylitol toxicity may arise as quickly as 30 to 60 minutes after ingestion.
The symptoms of poisoning vary depending on substance, the quantity a dog has consumed, the breed and size of the mammal.A common list of symptoms are digestion problems, such as vomiting, diarrhea, or blood in stool; bruising and bleeding gums, nose, or inside the ear canal; behavioral changes, such as lethargy, hyperactivity, and seizures; unusual items found in the dog's stool.
Alcoholic beverages are extremely harmful to dogs, [72] and often for reasons of additives such as xylitol, an artificial sweetener in some mixers. Dogs can absorb ethyl alcohol in dangerous amounts through their skin as well as through drinking the liquid or consuming it in foods. Even fermenting bread dough can be dangerous to dogs. [73]
The safety of sugar substitutes is once again being called into question. Xylitol is associated with an increased risk of heart attack and stroke, according to new Cleveland Clinic research.
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Macroscopic manifestations of neurotoxin exposure can include widespread central nervous system damage such as intellectual disability, [5] persistent memory impairments, [16] epilepsy, and dementia. [17] Additionally, neurotoxin-mediated peripheral nervous system damage such as neuropathy or myopathy is common.
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Trident gum contains the sugar alcohol xylitol, which is known as a "tooth-friendly" sugar. [3] Use of the chemical has been subject to controversy, as it is highly toxic to dogs. [4] [5] Trident has been sued for false labeling over its depiction of a blue mint leaf on its Trident original-flavor gum when the gum lacks any real mint. [6]