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Dihydrotestosterone ... selective agonist of the estrogen ... and characterization of 5α-reductase type 2 deficiency in 1974. [14] DHT was the last ...
DHT plays a key role in the process of sexual differentiation in the external genitalia and prostate during the development of the male fetus. 5αR2D is a result of impaired 5αR2 activity resulting in decreased DHT levels. Many people with 5-alpha reductase deficiency are assigned female at birth based on their
17β-Hydroxysteroid dehydrogenase 3 deficiency: impairs androgen and estrogen metabolism; results in androgen deficiency in males and androgen excess and estrogen deficiency in females [citation needed] 5α-Reductase 2 deficiency: prevents the conversion of testosterone to dihydrotestosterone; causes androgen deficiency in males [citation needed]
Low testosterone or testosterone deficiency, ... and some of its metabolites — like dihydrotestosterone ... that gynecomastia may occur due to an imbalance between estrogen and androgen hormones
Androstanolone, or stanolone, also known as dihydrotestosterone (DHT) and sold under the brand name Andractim among others, is an androgen and anabolic steroid (AAS) medication and hormone which is used mainly in the treatment of low testosterone levels in men. [2]
Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism [2] which is caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological effects in the body. [3]
The condition, known as 5α-reductase 2 deficiency, has a range of presentations as atypical appearances of the external genitalia in males. This is because 5α-reductase 2 catalyzes the transformation of testosterone to the potent androgen dihydrotestosterone, which is required for the proper masculinization of male genitalia. [30]
The team looked at individual patient data to understand relationships between baseline hormone concentrations (total testosterone; sex hormone-binding globulin, luteinizing hormone ...