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In a prospective randomized controlled trial comparing anterior temporal lobectomy to medical therapy for pharmacoresistant temporal lobe epilepsy, surgery was more effective than medical therapy with 1-year seizure free outcome occurring in 58% of persons with anterior temporal lobectomy compared to 8% of persons with drug treatment. [5]
Hence temporal lobe resection, during which the whole temporal lobe or just a part of the temporal lobe (for example, the hippocampus or the amygdala) is removed, is the most common epilepsy surgery procedure. Between 40 and 60% of patients who undergo temporal lobe resection are continuously seizure-free.
Temporal lobe resection acts as a treatment option for patients with temporal lobe epilepsy, or those whose seizure focus is in the temporal lobe. Temporal lobe seizures are the most common type (approximately 30% of diagnoses) of seizures for teens and young adults. [27] The procedure involves resecting, or cutting away, brain tissue within ...
The strongest evidence supporting ATL over continued medical therapy for medically refractory temporal lobe epilepsy is a prospective, randomized trial of ATL compared to best medical therapy (anticonvulsants), which convincingly demonstrated that the seizure-free rate after surgery was about 60% as compared to only 8% for the medicine only ...
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. [10] An epileptic seizure is the clinical manifestation of an abnormal, excessive, and synchronized electrical discharge in the neurons. [1]
The risk of sudden death in young adults with epilepsy is increased 20-40-fold compared to the general population. [32] [33] [20] SUDEP is the number one cause of epilepsy-related death in people with pharmacoresistant epilepsy. [20] Children with epilepsy have a cumulative risk of dying suddenly of 7% within 40 years. [20]
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