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19645 Ensembl ENSG00000139687 ENSMUSG00000022105 UniProt P06400 P13405 RefSeq (mRNA) NM_000321 NM_009029 RefSeq (protein) NP_000312 NP_000312.2 NP_033055 Location (UCSC) Chr 13: 48.3 – 48.6 Mb Chr 14: 73.42 – 73.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The retinoblastoma protein (protein name abbreviated Rb or pRb ; gene name abbreviated Rb, RB or RB1) is a tumor ...
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB.
238247 Ensembl ENSG00000032219 ENSMUSG00000048118 UniProt P29374 F8VPQ2 RefSeq (mRNA) NM_002892 NM_023000 NM_023001 NM_001081195 RefSeq (protein) NP_002883 NP_075376 NP_075377 NP_001074664 Location (UCSC) Chr 14: 58.3 – 58.37 Mb Chr 12: 71.02 – 71.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which ...
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
Simian virus (SV) 40 has been linked in studies to the development of choroid plexus tumors (CPTs). [6] The BK and JC viruses have also been linked to the problem. [7] In people with choroid plexus tumors, complexes formed by the big T antigen and the tumor suppressor proteins p53 and pRb have been shown to develop. [7]
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
PRB (company) ... Retinoblastoma protein, pRb, an important tumour-suppressor gene in retinoblastoma; ... This page was last edited on 10 January 2023, at 01:51 (UTC).
In the children with inherited retinoblastoma, the first mutation in what later came to be identified as the RB1 gene, was inherited, the second one acquired. In non-inherited retinoblastoma, instead two mutations, or "hits", had to take place before a tumor could develop, explaining the later onset.