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2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).
Upon reaching the plasmalemma, the vesicles fuse with the membrane, increasing the number of GLUT4 transporters expressed at the cell surface, and hence increasing glucose uptake. GLUT4 has a Km value for glucose of about 5 mM, which as stated above is the normal blood glucose level in healthy individuals.
A level below 5.6 mmol/L (100 mg/dL) 10–16 hours without eating is normal. 5.6–6 mmol/L (100–109 mg/dL) may indicate prediabetes and oral glucose tolerance test (OGTT) should be offered to high-risk individuals (old people, those with high blood pressure etc.). 6.1–6.9 mmol/L (110–125 mg/dL) means OGTT should be offered even if other ...
Deoxyglucose may refer to: 1,5-Anhydroglucitol (1-deoxyglucose) 2-Deoxy-D-glucose (2-deoxyglucose) This page was last edited on 5 February ...
The uptake of [18 F]FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After [ 18 F]FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of [ 18 F]FDG within the body.
The glucose tolerance test was first described in 1923 by Jerome W. Conn. [4]The test was based on the previous work in 1913 by A. T. B. Jacobson in determining that carbohydrate ingestion results in blood glucose fluctuations, [5] and the premise (named the Staub-Traugott Phenomenon after its first observers H. Staub in 1921 and K. Traugott in 1922) that a normal patient fed glucose will ...
Coupled assay for hexokinase using glucose-6-phosphate dehydrogenase. Even when the enzyme reaction does not result in a change in the absorbance of light, it can still be possible to use a spectrophotometric assay for the enzyme by using a coupled assay. Here, the product of one reaction is used as the substrate of another, easily detectable ...
It is responsible for the low level of basal glucose uptake required to sustain respiration in all cells. Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. GLUT1 expression is upregulated in many tumors. GLUT2: Is a bidirectional transporter, allowing glucose to flow in 2 directions.