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2. Peripherally acting μ-opioid receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Peripherally_acting_μ...

   Opioid drugs are known to cause opioid-induced constipation (OIC) by inhibiting gastric emptying and decreasing peristaltic waves leading to delayed absorption of medications and more water absorption from the feces. That can result in hard and dry stool and constipation for some patients. [2]

3. Methylnaltrexone - Wikipedia

   en.wikipedia.org/wiki/Methylnaltrexone

   Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

4. Naldemedine - Wikipedia

   en.wikipedia.org/wiki/Naldemedine

   Naldemedine, sold under the brand name Symproic in the US and Rizmoic in the European Union, is a medication that is used for the treatment of opioid-induced constipation in adults who have previously been treated with a laxative in the European Union, or to treat opioid induced constipation in adults with chronic non-cancer pain in the US.

5. Opioid antagonist - Wikipedia

   en.wikipedia.org/wiki/Opioid_antagonist

   Naltrexone is also a partial inverse agonist, and this property is exploited in treatment of opioid addiction, as a sustained course of low-dose naltrexone can reverse the altered homeostasis which results from long-term abuse of opioid agonist drugs. This is the only treatment available which can reverse the long-term after effects of opioid ...

6. List of opioids - Wikipedia

   en.wikipedia.org/wiki/List_of_opioids

   20 Combination drug formulations containing opioids. ... This is a list of opioids, opioid antagonists and inverse agonists. ... List of Schedule I drugs (US) Gray death;

7. Naloxegol - Wikipedia

   en.wikipedia.org/wiki/Naloxegol

   Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]