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Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.
Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. [174] Ibuprofen * can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. [175] Naproxen (Aleve)* has a long half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting.
This breakdown of muscle protein leads to muscle weakness and lethargy. [8] Other potential complications from Cushing's in dogs include proteinuria, glomerulosclerosis, pancreatitis, and gallbladder mucocele. [4] A study of 66 dogs with Cushing's found 91% of dogs to have either polyuria or polydipsia, 79% to have polyphagia, and 77% to have ...
Fanconi syndrome or Fanconi's syndrome (English: / f ɑː n ˈ k oʊ n i /, / f æ n-/) is a syndrome of inadequate reabsorption in the proximal renal tubules [1] of the kidney.The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. [2]
Hence, British guidelines append the letter "P" to the stage of chronic kidney disease if protein loss is significant. [60] Stage 1: Slightly diminished function; kidney damage with normal or relatively high GFR (≥90 mL/min/1.73 m 2) and persistent albuminuria. Kidney damage is defined as pathological abnormalities or markers of damage ...
General signs and symptoms include depression, fever, weight loss, loss of appetite, loss of hair or fur and vomiting. Lymphoma is the most common cancerous cause of hypercalcemia (high blood calcium levels) in dogs. [9] It can lead to the above signs and symptoms plus increased water drinking, increased urination, and cardiac arrhythmias.
Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules [1] of the kidney. It is one cause of Fanconi syndrome , and is characterized by tubular proteinuria , excess calcium in the urine , formation of calcium kidney stones , nephrocalcinosis , and chronic kidney failure .
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