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In anatomy, the interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell membrane or the skin, and internal structures, such as organs, including muscles and the circulatory system. [1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph ...
Interstitial fluid is essentially comparable to plasma. The interstitial fluid and plasma make up about 97% of the ECF, and a small percentage of this is lymph. Interstitial fluid is the body fluid between blood vessels and cells, [8] containing nutrients from capillaries by diffusion and holding waste products discharged by cells due to ...
It is filled with interstitial fluid, including lymph. [5] Interstitial fluid provides the immediate microenvironment that allows for movement of ions, proteins and nutrients across the cell barrier. This fluid is not static, but is continually being refreshed by the blood capillaries and recollected by lymphatic capillaries. In the average ...
Because it is derived from interstitial fluid, with which blood and surrounding cells continually exchange substances, lymph undergoes continual change in composition. It is generally similar to blood plasma, which is the fluid component of blood. Lymph returns proteins and excess interstitial fluid to the bloodstream.
The ECF compartment is divided into the interstitial fluid volume – the fluid outside both the cells and the blood vessels – and the intravascular volume (also called the vascular volume and blood plasma volume) – the fluid inside the blood vessels – in a three-to-one ratio: the interstitial fluid volume is about 12 liters; the vascular ...
The fluid bathes the tissues as interstitial fluid, collecting waste products, bacteria, and damaged cells, and then drains as lymph into the lymphatic capillaries and lymphatic vessels. These vessels carry the lymph throughout the body, passing through numerous lymph nodes which filter out unwanted materials such as bacteria and damaged cells.
When pressure is greater in the interstitial fluid than in lymph, the cells separate slightly, like the opening of a one-way swinging door, and interstitial fluid enters the lymphatic capillary. When pressure is greater inside the lymphatic capillary, the cells adhere more closely, and lymph cannot escape back into the interstitial fluid.
Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term". [ 1 ] The composition of the extracellular space includes metabolites , ions , various proteins and non-protein substances (e.g. DNA, RNA, lipids, microbial products etc.), and particles such ...