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Wernicke encephalopathy (WE), also Wernicke's encephalopathy, [1] or wet brain is the presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B 1). [2]
Frequently, secondary to thiamine deficiency and subsequent cytotoxic edema in Wernicke encephalopathy, patients will have marked degeneration of the mammillary bodies. Thiamine (vitamin B 1) is an essential coenzyme in carbohydrate metabolism and is also a regulator of osmotic gradient. Its deficiency may cause swelling of the intracellular ...
Wernicke's encephalopathy is the most frequently encountered manifestation of thiamine deficiency in Western society, [14] [15] though it may also occur in patients with impaired nutrition from other causes, such as gastrointestinal disease, [14] those with HIV/AIDS, and with the injudicious administration of parenteral glucose or ...
Wernicke syndrome is an ambiguous term. It may refer to: Wernicke aphasia: the eponymous term for receptive or sensory aphasia.; Wernicke encephalopathy: an acute neurological syndrome of ophthalmoparesis, ataxia, and encephalopathy brought on by thiamine deficiency.
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]
Carl (or Karl) [a] Wernicke (/ ˈ v ɛər n ɪ k ə /; German: [ˈvɛɐ̯nɪkə]; 15 May 1848 – 15 June 1905) was a German physician, anatomist, psychiatrist and neuropathologist.He is known for his influential research into the pathological effects of specific forms of encephalopathy and also the study of receptive aphasia, both of which are commonly associated with Wernicke's name and ...
Fluent speech: individuals with Wernicke's aphasia do not have difficulty with producing connected speech that flows. [6] Although the connection of the words may be appropriate, the words they are using may not belong together or make sense (Jargon). [11] Some patients with Wernicke's Aphasia experience logorrhea, which is also known as over ...
Rarer mimics of encephalopathy are meningitis, encephalitis, Wernicke's encephalopathy and Wilson's disease; these may be suspected on clinical grounds and confirmed with investigations. [9] [16] The diagnosis of hepatic encephalopathy is a clinical one, once other causes for confusion or coma have been excluded; no test fully diagnoses or ...