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As such, little data is available to guide dosage recommendations. [6] Three open non-comparative studies have been conducted to assess the safety and efficacy of ondansetron in children receiving a variety of chemotherapy regimens. [26] Ondansetron was well tolerated and none of the patients experienced extrapyramidal symptoms. [27]
The selection and use of essential medicines: report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl: 10665/259481. ISBN 978-92-4-121015-7. ISSN 0512-3054. WHO technical report series; no. 1006.
Drug Chemical nature Receptor antagonists T 1/2 (h) Metabolism Dose; Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5: 10 μg/kg Dolasetron: Indole: 5-HT 3 receptor antagonist 7 ...
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The first ODTs disintegrated through effervescence rather than dissolution, and were designed to make taking vitamins more pleasant for children. [16] This method was adapted to pharmaceutical use with the invention of microparticles containing a drug, which would be released upon effervescence of the tablet and swallowed by the patient. [17]
It can also help patients deal with the agitation that can occur when you first start taking an SSRI. Some research also suggests that SSRIs and benzodiazepines can be paired to treat GAD and help ...
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