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Cleft of the lip, palate, or both is one of the most common congenital abnormalities and has a birth prevalence rate ranging from 1/1000 to 2.69/1000 amongst different parts of the world (McLeod, Saeed, & Arana- Urioste, 2004).
Van der Woude syndrome (VDWS) is a genetic disorder characterized by the combination of lower lip pits, cleft lip with or without cleft palate (CL/P), and cleft palate only (CPO). [1] The frequency of orofacial clefts ranges from 1:1000 to 1:500 births worldwide, and there are more than 400 syndromes that involve CL/P. [2] VWS is distinct from ...
Holoprosencephaly-ectrodactyly-cleft lip/palate syndrome; Other names: Hartsfield syndrome [1] Specialty: Medical genetics: Diagnostic method: genetic testing, physical examination: Prevention: None: Prognosis: poor: Frequency: rare, about 35 cases have been described in the medical literature: Deaths: most patients are either stillborn or die ...
[1] [2] Cleft lip and cleft palate can often be diagnosed during pregnancy with an ultrasound exam. [1] A cleft lip or palate can be successfully treated with surgery. [1] This is often done in the first few months of life for cleft lip and before eighteen months for cleft palate. [1] Speech therapy and dental care may also be needed. [1]
Within craniofacial disorders and abnormalities, orofacial clefts, and specifically cleft lip (CL) and cleft palate (CP) are the most common in humans. [9] Occurrences of CL/P are most often (around seventy percent of cases) isolated and nonsyndromic, meaning they are not associated with a syndrome or inherited genetic conditions.
Roberts reported a disease that was characterized by phocomelia, cleft lip, cleft palate, and a protrusion of the intermaxillary region in three siblings of an Italian couple who were first cousins, which made Roberts syndrome acquisition more likely for their children due to the disease's autosomal recessive nature.
Frequency: 1 in 10,000 ... (BOFS), hemangiomatous branchial clefts-lip pseudocleft syndrome ... with or without hearing impairment, cleft lip/palate, and/or ...
Maxillary hypoplasia is the most common secondary deformity that results from cleft lip and cleft palate. Because of the subjective nature of the diagnosis, the incidence of maxillary hypoplasia in people with cleft lip and palate varies between 15-50%. It is estimated that 25-50% of these patients require surgical intervention. [7]