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Furosemide was patented in 1959 and approved for medical use in 1964. [6] It is on the World Health Organization's List of Essential Medicines. [7] In the United States, it is available as a generic medication. [4] In 2022, it was the 24th most commonly prescribed medication in the United States, with more than 23 million prescriptions.
The Food and Drug Administration (FDA) in the United States reports that there are six million pregnancies with at least 50% of the women taking at least one medication. [6] In addition a reported 5–10% of women of childbearing age use alcohol or other addictive substances. [7]
Aldosterone antagonists, also known as mineralocorticoid receptor antagonists: [7] Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent; Finerenone – non-steroidal, more selective and potent than spironolactone and eplerenone; Canrenone – very limited use
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Enalapril was patented in 1978, and came into medical use in 1984. [7] It is on the World Health Organization's List of Essential Medicines . [ 8 ] In 2022, it was the 141st most commonly prescribed medication in the United States, with more than 4 million prescriptions.
These spring soup recipes will usher in the new season. Try fresh vegetable flavors, including cream of asparagus, split pea, and potato leek.
This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. It was patented in 1966 and approved for medical use in 1974. [1]
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